Accumulating oocytes or blastocyst for low responders? Age as a criterion
August 08, 2013Accumulating Oocytes or Blastocysts for Low Responders? Age as a Criterion
| Author | Shih-Chieh Huang, Huai-Ling Wang, Wen-Yi Jiang, Hsing-Hua Chou, Hsing-Hua Lai |
|---|---|
| Editor | Hsing-Hua Chou |
| Seminar name | 2012Asia Pacific Initiative on Reproduction |
| Keyword | Blastocyst vitrification, oocyte vitrification, DOR |
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Low responders (LRs) are mostly from diminished ovarian reserve and/or advanced maternal age. They may experience repeated IVF failure caused by few or no embryos to transfer. In this cohort, accumulating oocytes or blastocysts to obtain more embryos could be benefit in improving clinical pregnancy rate (CPR). Several studies have shown maternal age as a determining factor in IVF treatment. In this study, we compared IVF outcome between two groups with oocyte or blastocyst accumulation at different age levels.
Methods
The patient were divided into 3 groups according to their treatment procedures:
Results
1.Comparison of fertilization, embryo development and clinical pregnancy rates between fresh and vitrified oocytes
2.Evaluation of age effect on oocyte or blastocyst accumulation
Conclusion
● For LR < 38 years old: accumulation of oocytes is recommended; by which CPR could be achieved and the cost is lower.
● For LR ≥ 38 years old: accumulation of blastocysts is recommended, because CPR could still be achieved through warmed BT whereas it is low in O-D3ET.
Reference
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- ●Cobo, A. (2012). Accumulation of oocytes: a new strategy for managing low-responder patients. Reprod Biomed Online 24(4), pp. 424-32.
- ●Geraedts, J. (2011). Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results. Hum Reprod 26(11), pp. 3173-80.
- ●Kuwayama, M. (2007). Highly efficient vitrification for cryopreservation of human oocytes and embryos: The Cryotop method. Theriogenology 67, pp. 73–80.
- ●Rienzi, L. (2010). Embryo development of fresh ‘versus’ vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study. Hum Reprod 25(1), pp. 66–73.